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Replenix Skin Care is manufactured by Topix Pharmaceuticals, a leading manufacturer of private label skin care products. Topix Replenix is an innovative, antioxidant based anti aging range that has numerous patent pending formulas. The Topix Replenix Research and Development department is located at their FDA-approved facility in Amityville, NY. Its worthwhile noting that most skin care products are developed by private label manufacturers, however, Topix Replenix has in-hour R&D and manufacturing resources, which gives them a unique advantage over most skin care brands. In fact, Topix Pharmaceuticals manufactures on behalf of many well known skin care brands and has been in business for over 20 years.

The Topix Replenix skin care range features 15 products, including: Replenix Fortified Cleanser, Replenix All-trans-Retinol Smoothing Serum 3X, Replenix Retinol Plus Smoothing Serum 10X, Replenix All-trans-Retinol Smoothing Serum 3X, Replenix All-trans Retinol Smoothing Serum 2X,  Replenix, All-trans-Retinol Smoothing Serum 3X, Replenix All-trans Retinol Smoothing Serum 2X, Replenix CF Cream, Replenix All-trans-Retinol Eye Repair Cream, Replenix Retinol Plus Smoothing Serum 5X and Replenix Retinol Plus Smoothing Serum 10x. We evaluated the earlier mentioned products, however, we spent much more time using the Replenix Retinol Plus Smoothing Serum 10x and found this to be one of the most exceptional retinol creams available on the market. Topix Replenix has shared before and after photos on its website and these results were consistent with what our test patient experienced.

Choosing the right skin care product is one of the most important parts of any beauty routine, well, anybody over 30 who isnt blessed with perfect looking skin. It is also one of the most difficult decisions you’ll need to make as there are hundreds of products – all claiming to be the best – and the wrong choice will not only guard against aging but certain ingredients can accelerate aging. Do these products work? We put Replenix to the test.Replenix’s primary active ingredients are Polyphenol Isolates – potent antioxidants derived from green tea. However, Replenix also utilises retinol is most of its product. Our favorite product in the range is Replenix Retinol Plus Smoothing Serum 10X. This is one of the most potent retinol treatments available right now.  If you have not used retinol based product or have sensitive skin, we recommend starting with Replenix Retinol Plus Smoothing Serum 5. If your skin does not react after a few applications, you can consider upgrading to the higher concentration serum. Whilst the cost of the product is $84, a little goes a long way, making it affordable in the long term.

Replenix product are available from Dermstore, SkinStore, SkinCare RX, LovelySkin, Dermatologist RX, Dr Bailey Skincare, Skin1 and skin clinics across America. Replenix products can be purchased directly from the Topix Replenis website. Replenix products include soothing cleansers, moisturizing lotions, treatment serums, eye creams and sun protection products. Prices vary from $20-120. Replenix products have been featured in InStyle, WH Beauty, Allure Magazine and Real Simple Magazine.




  1. sursattie

    I have never use it but just read the reviews, i am interested in trying it. Replinix retinol smoothing serum 10x. Thanks.

  2. Elizabeth

    I’ve been pleased with products from the Topix Glycolix brand and would be interested to sample the Replenix products, if still available. Thanks!

  3. Replenix Retinol

    How do Replenix retinol products compare to prescription retina or tretinoin cream? Over the counter retinol products are generally much lighter and do not work as well as prescription products. This looks like a doctor only brand.

    • Janis

      I am 58 yrs old and have tried EVERYTHING. My dermatologist gave me Replenix and I am sold. I will never again waste my money on any other product again. Removes wrinkles, firms and smoothes. I have used it for 1 year and love love love it. I look 45 now.

  4. Michelle T

    Hello, I was contemplating going to the dermatologists to get a retinol based serum. I would like to sample The REPLENIX 10X retinol. Thank you for your gratuitous nature.


  5. Toots

    Hello, I am a 58 year old female.
    I use many different skin care brands but I have stuck with one when it comes to Retinol.
    I am a loyal user of Replenix All-trans-Retinol Smoothing Serum 3X. It’s a potent form of retinol and it does not cause all that much irritation.
    I have not tried other Topix Replenix products and I was recommended this product by a friend who has tried many different retinol based products.

  6. Lucy

    I live in North Dakota and we get very dry air in winter. I have dry skin and concerned with wrinkles and uneven skin tone. I have some age spots. I start my regimen with Replenix Gentle Antioxidant Soothing Cleanser and apply the Topix Replenix All-trans-Retinol Smoothing Serum 3X aftewards. At night I also use Replenix Dermal Restructuring Therapy. They are all good products.

  7. Mimi

    I use the topix replenix retinol smoothing serum and green tea serum. Both are brilliant products. I use the strong retinol product. The lighter one doesn’t do anything. I know the results from retinol are only short acting but I like the the way my skin looks when I use it. I think its the irritation in the retinol that causes the skin to become thicker. I wonder if it is inflammation that is causing the wrinkles to appear less visible. Maybe it is not but it sure looks good short term.

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