Matrixyl, Matrixyl 3000 and Matrixyl synthe’6® are anti wrinkle formulas developed by cosmetic chemical manufacturer Sederma and incorporated by skin care companies in creams. Sederma is a subsidiary of French chemical company Croda who manufacturers chemicals for home, health and crop care. Matrixyl is found in numerous cream based moisturizers, serums, cleansers and lotions. Sederma claims the product restores skin’s metabolism of youth by simulating synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. Matrixyl combines two peptides, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide, resulting in an entirely new super peptides. Numerous skin care brands incorporate into their formulas and usually combine the ingredient with other anti wrinkle ingredients. The recommended dosage of Matrixyl is 2%, however, often manufacturers use lower or higher percentages based on their marketing claims. The latest addition to the Matrixyl family is Matrixyl ®synthe’6, which boosts skin’s rebuilding essentials. The ingredients are slightly different and include hydroxypropyl Cyclodextrin and Palmitoyl Tripeptide-38.

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Our #1 Recommendation is the Advanced Dermatology regimen. Find out more. Click here. 


  1. Anna Phillips

    I have practically taken 10 years off my face by doing the following. Increased water consumption. Carrot, apple broccoli, spinach and lemon juice(Juice in juicer) The trampoline increased my circulation 10 fold. A visit to the Esthetician where I had a micro dermabrasion followed by glycolic peel. I use Vit C serum/hyaluronic acid, retinol cream and vitamin B3/B5 serum all for about $27. And at nights I put pure aloe vera gel on my face and slept with it. I also do face exercises freelance. The difference is outstanding. I have a much clearer softer and firmer look. The creams alone are not gonna do it people. And don’t forget lots of sunscreen. Use products with glycerin and hyaluronic acid. They are cheap and highly effective. Lots of all those big names that we cannot pronounce are there to deceive in order to pump up price. Next time Im gonna try pure gelatin as a facial mask. After all isin’t that protein? For now I use eggs and the tightening is exceptional.

    • Anna Phillips

      And don’t forget a good night’s rest. Try not to sleep on your face in the pillow because gravity will pull it down. Sleep on your back or lightly to the side. Crucial is to keep the hormones balanced. A hormonal imbalance will defeat any good skin care regime that you have. There are bio-identical creams available. I have a good estriol cream that has worked wonders on my aging neck.

  2. Anonymous

    Look at what the previous comment as it would be easy to find which products contain Matrixyl and Matrixyl 3000. If you see the ingredients below or search for them you will find products that contain this. Otherwise you could go to your drugstore and scan the anti aging products that contain these ingredients. Just look for: Glycerin, Aqua, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide. Not just one but all

  3. Stacy

    I just use Matrixyl 3000 Serum w/ Hyaluronic Acid. It cost $22 and you can buy it from Amazon. To be perfectly honest, I have not seen a result from this yet and want to try something new.

  4. Sarah

    Hi Tamara
    I would like to know where you can get matrixyl 3000 in a cream. This is the replacement or upgraded version of matrixyl but I cannot find any creams that contain matrixyl 3000. If you can make a skin care cream with matrixyl 3000 I will buy it from you.

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